Digestive enzymes

"Malaria causes more than two million deaths each year, but an expert multinational team battling the global spread of drug-resistant parasites has made a breakthrough in the search for better treatment" (McGill). Examining the way malaria parasites reproduce, a team led by John Dalton, has identified "a plan of attack" to develop new and urgently needed treatments, which combat malaria.

The secret lies in how the parasites propagate. "Malaria parasites live inside our red blood cells and feed on proteins". They break down the proteins to "use the proceeds (amino acids) as building blocks for their own proteins". Once they "a sufficient size they divide and burst out of the red cell, entering another and repeating the process until severe disease or death occurs."

Specialized digestive enzymes of the parasites "enable them to undertake this process." Researchers have now developed three-dimensional structures of these two enzymes and "demonstrated how drugs can be designed to disable the enzymes."

"By blocking the action of these critical parasite enzymes, we have shown that the parasites can no longer survive within the human red blood cell," Dalton explains. "The team is putting their findings into action immediately and is already pursuing anti-malarial drug development."

Publications: The discovery will be published in the Proceedings of the National Academy of Sciences, and is the result of collaboration including Australia’s Queensland Institute of Medical Research, Monash University and the University of Western Sydney, Wroclaw University of Technology in Poland and the University of Virginia in the U.S.

Read more about digestive enzymes and malaria

Source:
McGill University (2010, January 29). Breakthrough could lead to new treatment for malaria. ScienceDaily. Retrieved January 31, 2010, from http://www.sciencedaily.com¬ /releases/2010/01/100128165850.htm

The Threat of Drug Resistant Malaria

Recent tests indicate that the most common malaria strains are becoming resistant to combination treatments in vulnerable areas. "Selected trials" showed "high failure rates for some combinations" of medicines. Anti-malarial treatments must be questioned, particularly in susceptible regions (Wiley).

The most common type of malaria parasite causes uncomplicated malaria, which is a mild form of the disease. However, if this strain remains untreated, it can develop into a life-threatening condition. "Resistance" of this strain "to the older antimalarials has led the WHO to recommend treatments combining" a fast-acting drug with a "longer-lasting drug to combat resistance."

Malaria can be a difficult disease to cure and is most often treated with a combination of medicines. During the recent tests, "there were examples of treatment failure rates above 10% for all evaluated combinations." According to the WHO, this exceeds the "maximum allowable failure rate for a first line antimalarial" treatment.

A recently introduced drug, dihydroartemisinin-piperaquine, performed well when compared to the standard treatment of artemisinin-based combination therapies (ACTs). This new treatment "offers another potential first-line therapy for the disease".

"Patterns of resistance change from place to place and over time," so continued testing of infected individuals and monitoring of progress is necessary to ensure successful treatment. These research and medical programs are costly, and severely underfunded. If you would like to contribute money to malaria research, please visit the following sites.

Anti-malaria agencies:

• Roll Back Malaria Partnership: Index of non-profit organizations that fight malaria (and need donations)
• United Nations Foundation: With your donation you are helping us expand the worldwide fight against disease, poverty, climate change, and conflict

(Infectious bite is not currently accepting donations. Please see the appropriate agencies for information on donations)

Source:
Wiley-Blackwell. "Continued Vigilance Against Drug-resistance Malaria Is Needed." ScienceDaily 7 July 2009. 9 July 2009 < http://www.sciencedaily.com­ /releases/2009/07/090707201209.htm >.

Malaria in Zimbabwe

Zimbabwe has received a bleak prognosis for 2009 regarding malaria and cholera cases. Cholera continues to surge at epidemic levels, high numbers of malaria cases are also expected. "Malaria may be worse in Zimbabwe in 2009" than it has been in previous years. "That's because efforts to control cholera may be diverting attention away from programs to prevent malaria. The warning comes from the Rollback Malaria Campaign" (DeCapua).

"It's not just the rainy season that's helping to spread" the diseases, "but also a weakened healthcare system and poor water and sanitation". The Rollback Malaria Campaign adds that "there's been much less indoor residual spraying against mosquitoes", "and current heavy rains will help increase the mosquito population." Treatment "kits to help manage severe malaria cases are not reaching those in need due to distribution problems and that there's a shortage of healthcare workers due to Zimbabwe's economic crisis" (DeCapua).

According to recent statistics, fewer than 7% of young children sleep under any kind of mosquito net. Since mosquitoes are most active at night, the use of a net is paramount in avoiding bites from the mosquitoes that may carry malaria.
For more statistics please visit the Zimbabwe country profile.

Bureaucratic bottlenecks have limited the program's effectiveness in Zimbabwe, but other challenges are even more difficult to overcome. "Problems with flow of global fund within country resulted the loss of part of funding" and there is a constant shortage of personnel (RBM Campaign).

However, there is good news for Zimbabwe. Malaria-related deaths fell between 2001 and 2007 largely because of malaria treatment programs.

The number of deaths is expected to rise in 2009 due to the projected increase in numbers of cases.

[Photo provided by the RBM Campaign]

Currently, "malaria is found in all areas of Zimbabwe except the city of Harare" (Uyaphi). According to the MD Travel Health Website, "Prophylaxis with Lariam, Malarone, or doxycycline" Malaria treatment "is recommended for all areas, except the cities of Harare and Bulawayo".


Malaria prevention in Zimbabwe is dependent of funds raised outside of the country. If you would like to donate to the RBM Campaign, please visit their donation page.

Advances Against Malaria | Reduction of Hospitalized Cases in Cambodia

Cambodian news sources are reporting a "50 percent drop in total malaria cases reported by public facilities between 2003 and last year, with officials crediting the success to village-based treatment" (Phnom).

"In 2008, 132,620 malaria patients were treated by village-based malaria volunteers, which has remarkably reduced the malaria death rate," according to the doctor of the National Centre for Parasitology, Entomology and Malaria Control.

Source:
LEAKHANA, KHUON AND CHRISTOPHER SHAY. The Phnom Penh Post. "Malaria cases at hospitals...". 24 June 2009.